An ex-cop, now working as a hack novelist, is called out of retirement to help investigate a string of deaths that appear to be the work of a serial killer but soon are revealed to be the work of th...

　　凡纳克精神疗养院内的研究人员曾进行秘密的生物试验，该试验造成病患和医护人员接连死亡。最终，该疗养院废弃，多年来荒凉阴森，无人敢近，成为远近闻名的恐怖鬼屋。　　性格怪异的亿万富翁史蒂芬•普莱斯（Geoffrey Rush杰佛瑞•罗许 饰）决定在凡纳克精神疗养院为妻子艾芙琳（Famke Janssen 芬卡•杰森 饰）举行一场别出心裁的生日派对，他邀请六个人前来，只要他们敢在这幢“鬼屋”中待上一晚...